What is one reason Native Americans suffered high fatality rates after European contact?

New diseases like smallpox.

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  1. Too much clean water
  2. Lack of horses
  3. New diseases like smallpox ✔

Why: Native peoples had no immunity to new European diseases, and smallpox was especially devastating.

Huh, didn't know that: Native peoples had no immunity to new European diseases, and smallpox was especially devastating.

The dad joke
That is a sick fact, sadly.
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References

Answer: New diseases like smallpox. Native peoples had no immunity to new European diseases, and smallpox was especially devastating.

  1. Native Americans in the United States en.wikipedia.org/wiki/Native_Americans_in_the_United_States
    Native Americans suffered high fatality rates from contact with European diseases that were new to them
    Checked 2026-11-07.

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